studies

state of research

Below is a clear overview of the studies that have been conducted to date, building on existing research into the core technologies "aPDT" and "Photobiomodulation," to directly analyze the effectiveness of "manadental" photodynamic care. This section is continuously updated with future results.

state of research

Below is a clear overview of the studies that have been conducted to date, building on existing research into the core technologies "aPDT" and "Photobiomodulation," to directly analyze the effectiveness of "manadental" photodynamic care. This section is continuously updated with future results.

01 | technology

Manadental photodynamic cleaning is based on antimicrobial photodynamic therapy (aPDT), a technology used to eliminate plaque bacteria. Bacteria are stained with a dye (photosensitizer) and then activated by light of an appropriate wavelength, leading to their elimination. In addition, manadental achieves positive effects of photobiomodulation (cf. LLLT/red light therapy) through the light source used, which can have cell-regenerating effects and improve tissue circulation. Below you can read about these technologies and the existing study situation. Under the section "Studies", analyses carried out with the manadental product based on the existing study situation are also listed.

MODE OF ACTION

Photodynamics

eliminates plaque

to studies

MODE OF ACTION

Photobiomodulation

aids tissue regeneration

to studies

MODE OF ACTION

Photodynamics

eliminates plaque

to studies

MODE OF ACTION

Photobiomodulation

aids tissue regeneration

to studies

02 | investigations

The manadental photodynamic care system to be used is characterized by simple application suitable for home use as an oral hygiene product, targeted irradiation dimensioning, and well-tolerated photosensitizers and/or ingredients. The cornerstones of the process are, on the one hand, the targeted effect of photodynamic treatment, which is limited to the "stained" germs, and, on the other hand, the fact that both photosensitizers and light penetrate areas that are otherwise inaccessible to home dental hygiene.

The "manadental" product, which was developed for the application of photodynamic care, is designed as an innovative instrument for daily oral hygiene and is intended to comprehensively protect and maintain oral health.

To analyze the effectiveness of the "manadental" photodynamic care, series of experiments were carried out in the laboratory (in vitro) and studies (in vivo) with test subjects. The examining institutes were the Institute for Hygiene and Microbiology at the Medical University of Graz and the DakkS accredited research institute Dermatest GmbH, based in Germany.

Medical University of Graz

99.9% more effective than conventional mouthwashes.

In-vitro test series on the antibacterial efficacy of a photodynamic system with riboflavin (vitamin B2) and a polychromatic LED light source against the pathogenic oral bacterium Streptococcus mutans.

for the study

Dermatest GmbH

49.4% improved gum health in 4 weeks.

Clinical-dental medical study on the efficacy of a
photodynamic care system on gum health measured by bleeding on probing (BoP) and plaque index (PI) over a 4-week observation period.

for the study

Andreas Inthal, DMD

84.0% feel their mouth is cleaner.

In Vivo Study on the Efficacy of a Photodynamic System with Riboflavin (Vitamin B2) and Polychromatic LED Light Source on Gingival Health, Measured by Bleeding-on-Probing (BoP).

to the study

References.

[1] Carrera, E., Dias, H. B., Corbi, S. C. T., Marcantonio, R. A. C., Bernardi, A. C. A., Bagnato, V. S., Hamblin, M. R. & De Souza Rastelli, A. N. (2016). The application of antimicrobial photodynamic therapy (aPDT) in dentistry: a critical review. Laser Physics, 26(12), 123001. https://doi.org/10.1088/1054-660x/26/12/123001

[2] Samra, A. P. B., De Carvalho, V. F., Godoy-Miranda, B., Kassa, C. T., Horliana, A. C. R. T. & Prates, R. A. (2021). Efficacy of antimicrobial photodynamic therapy (aPDT) for nonsurgical treatment of periodontal disease: a systematic review. Lasers in Medical Science, 36(8), 1573–1590. https://doi.org/10.1007/s10103-020-03238-1

[3] Azaripour, A., Dittrich, S., Van Noorden, C. J. & Willershausen, B. (2018). Efficacy of photodynamic therapy as adjunct treatment of chronic periodontitis: a systematic review and meta-analysis. Lasers in Medical Science, 33(2), 407–423. https://doi.org/10.1007/s10103-017-2383-7

[4] Wolf, Herbert, F.; M. Edith; & Rateitschak, Klaus, H. (2014). Farbatlanten der Zahnmedizin. Georg
Thieme Verlag eBooks, 1, 69–80. https://doi.org/10.1055/b-00000027

[5] Hellwig, Elmar; Schäfer, Edgar; Klimek, Joachim; Attin, Thomas (2018): Einführung in die Zahnerhaltung. Prüfungswissen Kariologie, Endodontologie und Parodontologie. 7. überarbeitet Auflage. Köln: Deutscher Zahnärzte Verlag. S.537-538

[6] Zahnfabrik, V. (n. d.). VITA Farbskalen. VITA Zahnfabrik. Retrieved on April 16, 2023, from https://www.vita-zahnfabrik.com/de/VITA-Farbskalen-31232.html

[7] Yaacob, M., Worthington, H. V., Deacon, S. A., Deery, C., Walmsley, G. D., Robinson, P. G., & Glenny, A. M. (2014). The efficacy of powered toothbrushes following a brushing exercise: a systematic review. International Journal of Dental 1 Hygiene, 12(3), 144–151. https://doi.org/10.1111/idh.12115